SYNOPSIS
Maggie (Hathaway) is an alluring free spirit who won't let anyone - or anything - tie her down. But she meets her match in Jamie (Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
- Jake GyllenhaalJamie Randall
- Anne HathawayMaggie Murdock
- Judy GreerCindy
- Oliver PlattBruce Winston
- Hank AzariaDr. Stan Knight
- Josh GadJosh Randall
- Gabriel MachtTrey Hannigan
- George SegalDr. James Randall
- Jill ClayburghNancy Randall
- Kate Jennings GrantGina
- Katheryn Winnick'Lisa'
- Kimberly ScottGail
- Peter FriedmanCalifornia Man
- Nikki DeloachChristy
- Natalie GoldDr. Helen Randall
- Megan FergusonFarrah
- Michael Benjamin WashingtonRichard
- Bingo O'MalleySam
- Dorothy SilverSophie
- Lucy RoucisUn-Convention Parkinson's Speaker
- Joan AugustinJoan
- Michael ChernusJerry
- Kate EastonAmber
- Michael BufferPfizer Convention MC
- Maite SchwartzTexas