The Epic Tales of Captain Underpants in Space

• 
  Nat Faxon
  Captain Underpants / Mr. Krupp
• 
  Jay Gragnani
  Harold
• 
  Ramone Hamilton
  George
• 
  Jorge Diaz
  Melvin / Stanley Peet / Melvin's Dad
• 
  Peter Hastings
  Comic Narrator
• 
  Dayci Brookshire
  Jessica / Dressy
• 
  David Koechner
  Mr. Meaner
• 
  Erica Luttrell
  Erica / George's Mom
• 
  Secunda Wood
  Moxie Swaggerman
• 
  Nolan North
  Dr. Shifty Fitzgibbons
• 
  Evan Kishiyama
  Steve 'Gooch' Yamaguchi
• 
  Gary Anthony Williams
  Dupe Licitous
• 
  Brennan Murray
  Bo Hweemuth
• 
  Laraine Newman
  Elbrib
• 
  Patty Mattson
  Miss Anthrope / Harold's Mom

• Seung Woo Cha
• Erik Kling
• Kevin Peaty

• Mark Banker
  ...
  (head writer)
• Daniel Domínguez
• John Matta
• Matt Smith
  ...
  (staff writer)

• Sean Astin