The New Adventures of Old Christine

• 
  Julia Louis-Dreyfus
  Christine Campbell
• 
  Clark Gregg
  Richard Campbell
• 
  Hamish Linklater
  Matthew Kimble
• 
  Trevor Gagnon
  Ritchie Campbell
• 
  Emily Rutherfurd
  Christine 'New Christine' Hunter
• 
  Tricia O'Kelley
  Marly Ehrhardt
• 
  Alex Kapp
  Lindsay
• 
  Wanda Sykes
  Barb Baran
• 
  Lily Goff
  Ashley Ehrhardt
• 
  Marissa Blanchard
  Kelsey
• 
  Blair Underwood
  Daniel Harris
• 
  Mary Beth McDonough
  Mrs. Wilhoite
• 
  Michaela Watkins
  Lucy
• 
  Jordan Baker
  Mrs. Belt
• 
  Eric McCormack
  Dr. Max Kershaw
• 
  Nancy Lenehan
  Principal Marcie Nunley
• 
  Matt Letscher
  Burton Schaefer
• 
  Scott Bakula
  'Papa Jeff' Hunter
• 
  Andy Richter
  Stan
• 
  Amy Farrington
  Ali
• 
  Tim DeKay
  Patrick Harris
• 
  Dave Foley
  Tom
• 
  James Lesure
  Dave
• 
  Ed Begley Jr.
  Pastor Ed
• 
  Charles Esten
  Joe Campbell
• 
  Lauren Bowles
  Patty
• 
  Tom Papa
  Mike
• 
  Lee Tergesen
  Todd Watski
• 
  Tim Meadows
  Dr. Volk
• 
  Stephen Tobolowsky
  Principal James Merrow

• Andy Ackerman

• Kari Lizer
  ...
  (creator)
• Jeff Astrof
• Katie Palmer
• Adam Barr
• Sherry Bilsing
• Ellen Kreamer
• Frank Pines
• Jennifer Crittenden
• Allan Rice
• Lew Schneider
• Danielle Evenson
• Amy Iglow
• Jack Burditt
• Jonathan Goldstein
• Steve Baldikoski
• Bryan Behar
• Matt Goldman
• Jackie Filgo
• Jeff Filgo
• Aaron Shure
• Charles Zucker
• Alex Kapp
• Tricia O'kelley

• Kari Lizer