The series follows Jessie Prescott, a young woman from a small town with big dreams who, rebelling against her strict father, decides to leave the military base in Texas where she grew up and moves to New York City. She accepts a job as a nanny and moves into a multi-million dollar penthouse on the Upper West Side with the wealthy Ross family which includes: jet-setting parents, Morgan and Christina; and their four rambunctious children: Emma, Luke, Ravi and Zuri; along with the family pet (and Ravi's companion) Mr. (later Mrs.) Kipling, a 7 ft (2 m) Asian water monitor, that was later revealed to be a female. With a whole new world of experiences open to her, Jessie embarks on new adventures in the big city as she grows to rely on the love and support of the children in her care. Assisting her are Bertram, the family's sarcastic butler, and Tony, the building's 20-year-old doorman.
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