Actor:
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1. Premium Blend (1997), series...Herself - Host
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...Chantal
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3. Curb Your Enthusiasm (2000), series...Wanda Sykes
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4. Down to Earth (2001), film...Wanda
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5. Pootie Tang (2001), film...Biggie Shorty
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6. The Ellen DeGeneres Show (2003), series...Self - Guest
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7. Da Boom Crew (2004), series...Special Guest Voice
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8. Monster-in-Law (2005), film...Ruby
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9. My Super Ex-Girlfriend (2006), film...Carla Dunkirk
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10. Barnyard (2006), film...Bessy the Cow (voice)
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11. Clerks 2 (2006), film...Wife
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12. Brother Bear 2 (2006), film...Innoko (voice)
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13. The New Adventures of Old Christine (2006), series...Barb Baran
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14. Evan Almighty (2007), film...Rita
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15. Wanda Sykes: I'ma Be Me (2009), film...Herself
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16. Rio (2011), film...Chloe (The Goose) (voice)
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17. The Out List (2013), film...Herself
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18. The Hot Flashes (2013), film...Florine Clarkston
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19. Broad City (2014), series...Dara
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20. Black-ish (2014), series...Daphne Lido
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21. Bad Moms (2016), film...Dr. Karl
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22. Chelsea (2016), series
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23. Bad Moms 2 (2017), film...Dr. Karl
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24. Snatched (2017), film...Ruth
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25. Vampirina (2017), series...Gregoria
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26. Talk Show the Game Show (2017), series...Self - Contestant
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27. Cultureshock (2018), series...Self
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28. Vampirina: Ghoul Girls Rock! (2018), series
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29. The Wedding Year (2019), film...Janet / Grandma
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30. Jexi (2019), film...Denice
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31. Wanda Sykes: Not Normal (2019), film...Self
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32. The Other Two (2019), series...Shuli Kucerac
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33. The Bravest Knight (2019), series...Mona the Mayor
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35. Friendsgiving (2020), film...Fairy Gay Mother #2
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36. Visible: Out On Television (2020), series
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37. Breaking News in Yuba County (2021), film...Rita
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38. Tiger (2021), series...Self - Comedian
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39. The Upshaws (2021), series
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40. Q-Force (2021), series
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41. Gutsy (2022), series...Self
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42. Stand Out: An LGBTQ+ Celebration (2022), film
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43. Wanda Sykes: I'm an Entertainer (2023), film...Self
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44. The Improv: 60 and Still Standing (2023), film...Self (archive footage)
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45. Albert Brooks: Defending My Life (2023), film...Self
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46. History of the World: Part II (2023), series...Shirley Chisholm
Writer:
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1. Wanda Sykes: I'ma Be Me (2009), film
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2. Wanda Sykes: Not Normal (2019), film
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3. History of the World: Part II (2023), series...(writer)
Producer:
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...executive producer
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2. Wanda Sykes: Not Normal (2019), film...executive producer
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...executive producer
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...executive producer
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...executive producer
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...executive producer
Voice:
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1. Over the Hedge (2006), film...Stella
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2. Barnyard (2006), film...Bessy the Cow
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3. Brother Bear 2 (2006), film...Innoko
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4. Hammy's Boomerang Adventure (2006), film...Stella
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5. The Adventures of Brer Rabbit (2006), film...Sister Moon
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6. Rio (2011), film...Chloe (The Goose)
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7. Ice Age: Collision Course (2016), film...Granny
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8. Ugly Dolls (2019), film...Wage
Director:
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1. The Upshaws (2021), series