The Magic School Bus Rides Again

• 
  Mikaela Blake
  Keesha
• 
  Gabby Clarke
  Dorothy Ann
• 
  Birva Pandya
  Jyoti
• 
  Kate McKinnon
  Ms. Fiona Frizzle
• 
  Leke Maceda-Rustecki
  Carlos
• 
  Lynsey Pham
  Wanda
• 
  Lily Tomlin
  Professor Frizzle
• 
  Matthew Mintz
  Ralphie
• 
  Miles KV
  Arnold
• 
  Annelise Forbes
  Janet
• 
  Lilly Bartlam
  Additional
• 
  Kaden Stephen
  Tim
• 
  Stuart Stone
  Additional
• 
  Marcus Craig
  Additional
• 
  Kevin Vidal
  Additional
• 
  Martin Roach
  Additional
• 
  Will Arnett
  Galapagos Gil
• 
  Catherine O'Hara
  Aunt Tennelli
• 
  Martin Short
  Tony Tennelli
• 
  Jay Baruchel
  Dr. Tillage

• Amos Crawley
• Lisa Jai
• Julie Lemieux
• Ana Sani
• Jamie Watson

• Richard Weston

• Suzanne Bolch
  ...
  (executive story editor)
• Joanna Cole
  ...
  (based on the Scholastic books written by)
• Jennifer Daley
• Bruce Degen
  ...
  (based on the book illustrated by)
• Merrill Hagan
• Brian Hartigan
• Evan Thaler Hickey
• Emma Kassirer
• John May
  ...
  (executive story editor)
• Mike McPhaden
  ...
  (writer)
• Bernice Vanderlaan
  ...
  (writer)
• Nathalie Younglai
  ...
  (writer)