Sissy Hankshaw (Uma Thurman) is born with enormous thumbs that help her hitchhiking through the US from a young age. She becomes a model in advertising and her NY agent 'the Countess' sends her to his ranch in CA to shoot a commercial, set against the background of mating whooping cranes. There, she befriends Bonanza Jellybean, one of the cowgirls at the beauty-ranch. The cowgirls take command of the ranch from the Countess and 'drug' the cranes with 'peyote'. The police besiege the ranch.